About the TrialTree Wiki

The TrialTree Wiki is a collaborative knowledge base dedicated to supporting the design, conduct, reporting, and interpretation of randomized trials. It serves as a centralized hub for researchers, methodologists, students, and anyone interested in evidence-based trial design.

Purpose

The Wiki aims to:

• Provide clear, accessible guidance on all aspects of randomized trials
• Foster best practices and transparency in trial design and reporting
• Serve as a living repository of methods, tools, and resources
• Support the use of the TrialTree© platform and other related trial design tools

Who is it for?

This wiki is designed for:

• Trialists and clinical researchers
• Biostatisticians and methodologists
• Ethics committee members and regulators
• Students and educators in health research

What does it include?

Key features of the TrialTree Wiki:

• Step-by-step guidance on designing RCTs
• Explanations of common and advanced trial methodologies
• Templates, checklists, and practical tools
• Real-world examples and case studies
• Links to relevant literature and standards (e.g., CONSORT, SPIRIT)

Contribution and Collaboration

This Wiki is meant to be a collaborative effort. Contributions from the research community are encouraged to keep content current, accurate, and relevant. If you'd like to contribute, contact us.

Acknowledgements

TrialTree Wiki was built by Dr Lawrence Mbuagbaw with the technical support of the mHealth and eHealth Development and Innovation Centre (MEDIC). This resource will be maintained by contributors affiliated with the TrialTree© platform and supported by a network of clinical research experts. We thank all collaborators and reviewers for their input.

Contact

For questions, feedback, or technical support, please contact us at: trialt.mcmaster.ca