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= Welcome to the Wiki Resource for TrialTree =
= Welcome to the Wiki Resource for TrialTree =
'''TrialTree''' is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It combines interactive tools, educational resources, and collaborative features to make trial design more accessible for everyone—from students and early-career researchers to experienced clinicians and investigators.


== What Is TrialTree? ==
== What Is TrialTree? ==
[[File:5.png|thumb|left|75px|The TrialTree logo]]'''TrialTree''' is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It combines interactive tools, educational resources, and collaborative features to make trial design more accessible for everyone—from students and early-career researchers to experienced clinicians and investigators.It offers a user-friendly, visual approach to trial design, making it accessible to researchers, clinicians, and students, even those with limited experience in clinical trial methodology. '''TrialTree''' helps users build scientifically rigorous and ethically sound clinical trials through step-by-step guidance, real-world examples, and collaborative tools.


[[File:5.png|thumb|center|300px|The TrialTree logo]]
'''TrialTree''' is a resource for anyone interested in improving the quality, ethics, and accessibility of clinical trials. Whether you're learning, designing, or teaching—'''TrialTree''' supports you every step of the way.
 
'''TrialTree''' is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It offers a user-friendly, visual approach to trial design, making it accessible to researchers, clinicians, and students, even those with limited experience in clinical trial methodology.
 
TrialTree helps users build scientifically rigorous and ethically sound clinical trials through step-by-step guidance, real-world examples, and collaborative tools.
 
''TrialTree is a resource for anyone interested in improving the quality, ethics, and accessibility of clinical trials. Whether you're learning, designing, or teaching—TrialTree supports you every step of the way.''


==Table of Contents==
==Table of Contents==
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{| class="wikitable" style="width:250px; background:#f9f9f9; border:1px solid #ccc; font-size:90%;"
{| class="wikitable" style="width:250px; background:#f9f9f9; border:1px solid #ccc; font-size:90%;"
|-
|-
! colspan="1" style="background:#336699; color:white; text-align:center;" | '''TrialTree Table of Contents'''
! colspan="1" style="background:#336699; color:white; text-align:center;" | '''TrialTree Wiki Table of Contents'''
|-
|-
| '''Trial Foundations'''
| <div class="mw-collapsible mw-collapsed">
* [[Research Question]]
'''Trial Foundations'''
* [[Hypothesis]]
<div class="mw-collapsible-content">
* [[Equipoise]]
* [[Research question]]
* [[Systematic Review]]
* [[Hypothesis]]
* [[Types of trials]]
* [[Equipoise]]
* [[SPIRIT]]
* [[Systematic review]]
* [[Types of trials]]
* [[SPIRIT]]
</div>
</div>
|-
|-
| '''Trial Design Types'''
| <div class="mw-collapsible mw-collapsed">
* [[Cluster randomized trials]]
'''Trial Design Types'''
* [[Cross-Over Trials]]
<div class="mw-collapsible-content">
* [[Stepped wedge trials]]
* [[Cluster randomized trials]]
* [[Factorial Trials]]
* [[Cross-over trials]]
* [[Pragmatic trials]]
* [[Stepped wedge trials]]
* [[Pilot and feasibility trials]]
* [[Factorial trials]]
* [[Vanguard Trials]]
* [[Pragmatic trials]]
* [[Multi-Arm Trials]]
* [[Pilot and feasibility trials]]
* [[MAMS]]
* [[Vanguard trials]]
* [[Platform Trials]]
* [[Multi-arm trials]]
* [[Non-Inferiority Trials]]
* [[Multi-arm multi-stage trials]]
* [[N-of-1 trials]]
* [[Platform trials]]
* [[Expertise-Based Trials]]
* [[Non-inferiority trials]]
* [[N-of-1 trials]]
* [[Expertise-based trials]]
* [[Phases of trials]]
* [[Group sequential trials]]
* [[Implementation trials]]
* [[Hybrid trials]]
* [[Registry-based trials]]  
</div>
</div>
|-
|-
| '''Oversight & Participants'''
| <div class="mw-collapsible mw-collapsed">
* [[Data Safety and Monitoring Board]]
'''Oversight & Participants'''
* [[Trial Participants]]
<div class="mw-collapsible-content">
* [[Trial Interventions]]
* [[Data Safety and Monitoring Board]]
* [[Trial Controls]]
* [[Trial participants]]
* [[Trial Outcomes]]
* [[Trial interventions]]
* [[TiDier]]
* [[Trial controls]]
* [[Patient and Public Involvement]]
* [[Trial outcomes]]
* [[TIDieR]]
* [[Patient and public involvement]]
* [[Equity-relevant trials]]
* [[Equity-relevant trials]]
* [[Quality of life measures]]
* [[Patient-reported outcomes]]
* [[Ethics]]
* [[Informed consent]] 
</div>
</div>
|-
|-
| '''Randomization'''
| <div class="mw-collapsible mw-collapsed">
* [[Randomization]]
'''Randomization'''
* [[Implementing randomization]]
<div class="mw-collapsible-content">
* [[Allocation concealment]]
* [[Randomization]]
* [[Implementing allocation concealment]]
* [[Implementing randomization]]
* [[Minimization]]
* [[Allocation concealment]]
* [[Stratification]]
* [[Implementing allocation concealment]]
* [[Minimization]]
* [[Stratification]]
</div>
</div>
|-
|-
| '''Blinding & Bias'''
| <div class="mw-collapsible mw-collapsed">
* [[Blinding]]
'''Blinding & Bias'''
* [[Implementing blinding]]
<div class="mw-collapsible-content">
* [[Preventing Attrition]]
* [[Blinding]]
* [[Implementing blinding]]
* [[Preventing attrition]]
* [[Internal and external validity]]
</div>
</div>
|-
|-
| '''Analysis & Interpretation'''
| <div class="mw-collapsible mw-collapsed">
* [[Statistical Analysis Plan (SAP)]]
'''Analysis & Interpretation'''
* [[Sample Size]]
<div class="mw-collapsible-content">
* [[Analysis of Trials]]
* [[Statistical Analysis Plan (SAP)]]
* [[Intention-to-Treat (ITT) Analysis]]
* [[Sample size]]
* [[Per-Protocol (PP) Analysis]]
* [[Analysis]]
* [[Subgroup Analysis]]
* [[Intention-to-treat analysis]]
* [[Sensitivity Analyses]]
* [[Per-protocol analysis]]
* [[Multiple Testing]]
* [[Subgroup analysis]]
* [[Statistical vs. Clinical Significance]]
* [[Sensitivity analysis]]
* [[Multiple testing]]
* [[Clinical versus statistical significance]]
* [[Frequentist and Bayesian approaches]] 
</div>
</div>
|-
|-
| '''Cost & Scalability'''
| <div class="mw-collapsible mw-collapsed">
* [[Cost effectiveness]]
'''Cost & Scalability'''
* [[Scaling up]]
<div class="mw-collapsible-content">
* [[Budgeting]]
* [[Cost effectiveness]]
* [[Scaling up]]
* [[Budgeting]]
</div>
</div>
|-
|-
| '''Data & Documentation'''
| <div class="mw-collapsible mw-collapsed">
* [[Database Creation]]
'''Data & Documentation'''
* [[Data Management Plans (DMP)]]
<div class="mw-collapsible-content">
* [[Missing Data]]
* [[Database creation]]
* [[Data management plan (DMP)]]
* [[Missing data]]
* [[Digital tools]]
</div>
</div>
|-
|-
| '''Reporting Guidelines'''
| <div class="mw-collapsible mw-collapsed">
* [[CONSORT]]
'''Reporting Guidelines'''
* [[SPIRIT]]
<div class="mw-collapsible-content">
* [[CONSORT]]
* [[SPIRIT]]
</div>
</div>
|}
|}
== 💬 Join the Community ==
TrialTree is continuously growing and evolving. Collaborate, share your work, and help others design better trials.
----
''TrialTree is a resource for anyone interested in improving the quality, ethics, and accessibility of clinical trials. Whether you're learning, designing, or teaching—TrialTree supports you every step of the way.''
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== Link To Test Page ==
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Latest revision as of 17:03, 28 June 2025

Welcome to the Wiki Resource for TrialTree

What Is TrialTree?

The TrialTree logo

TrialTree is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It combines interactive tools, educational resources, and collaborative features to make trial design more accessible for everyone—from students and early-career researchers to experienced clinicians and investigators.It offers a user-friendly, visual approach to trial design, making it accessible to researchers, clinicians, and students, even those with limited experience in clinical trial methodology. TrialTree helps users build scientifically rigorous and ethically sound clinical trials through step-by-step guidance, real-world examples, and collaborative tools.

TrialTree is a resource for anyone interested in improving the quality, ethics, and accessibility of clinical trials. Whether you're learning, designing, or teaching—TrialTree supports you every step of the way.

Table of Contents

TrialTree Wiki Table of Contents

Reporting Guidelines