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Welcome to the Wiki Resource for TrialTree
TrialTree is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It combines interactive tools, educational resources, and collaborative features to make trial design more accessible for everyone—from students and early-career researchers to experienced clinicians and investigators.
What Is TrialTree?

TrialTree is an innovative online platform designed to simplify the process of designing, learning about, and managing clinical trials. It offers a user-friendly, visual approach to trial design, making it accessible to researchers, clinicians, and students, even those with limited experience in clinical trial methodology.
TrialTree helps users build scientifically rigorous and ethically sound clinical trials through step-by-step guidance, real-world examples, and collaborative tools.
🔑 Key Features
1. Interactive Trial Design
- Create, customize, and visualize trial protocols step by step.
- Guided decisions on:
- Randomization methods
- Blinding
- Sample size calculation
- Outcome selection
- Supports various trial types:
- Parallel
- Crossover
- Factorial
- Cluster
- Stepped-wedge
2. Educational Tool
- Learn clinical trial principles in a hands-on way.
- Access examples and templates for common and complex trial designs.
- Ideal for students, trainees, and early-career researchers.
3. Collaboration and Sharing
- Share trial designs with collaborators in real time.
- Export and distribute protocols for feedback and discussion.
- Foster teamwork in research environments.
4. Focus on Equity and Inclusion
- Tools and guidance for designing equity-relevant trials.
- Support for incorporating:
- Diversity in participant recruitment
- Culturally responsive interventions
- Inclusive outcome measures
5. Real-World Application
- Build trial protocols suitable for ethical approval and real implementation.
- Supports research across a range of disciplines including:
- HIV prevention and care
- Chronic disease management
- Global health and public health trials
🌟 Why TrialTree Is Unique
- Simplifies trial design for non-experts without sacrificing scientific rigor.
- Offers advanced features for experienced trialists.
- Bridges the gap between learning about trials and conducting them.
- Promotes equity and inclusivity in all stages of trial development.
📚 Get Started
- Types of Trials
- Formulating a Research Question
- Equipoise in RCTs
- Hypotheses in Clinical Trials
- Systematic Reviews Before RCTs
- Statistical Analysis Plans (SAPs)
💬 Join the Community
TrialTree is continuously growing and evolving. Collaborate, share your work, and help others design better trials.
TrialTree is a resource for anyone interested in improving the quality, ethics, and accessibility of clinical trials. Whether you're learning, designing, or teaching—TrialTree supports you every step of the way.
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